Description
CatechinisaflavanoloriginallyfoundinCamillaandotherplantsources;itexhibitsantioxidative,anti-aging,anti-atherosclerotic,anti-ulcerative,neuroprotective,neuromodulatory,anticancerchemotherapeutic,andchemopreventiveactivities.CatechinincreaseslifespaninCaenorhaBDitiselegansandinhibitsmonoamineoxidaseB(MAO-B)invitro.Catechindecreasesatheroscleroticlesionarea,suppressesleukocyteadhesion,andinhibitsLDLoxidationanduptakeinanimalmodelsofatherosclerosis.Inanimalmodelsofbrainhemorrhage,catechinincreasersactivityofNrf2andphaseIIdetoxifyingenzymes,inhibitingoxidativestress,neurologicaldeficits,andlesionformation.Inotheranimalmodels,catechininhibitshistidinedecarboxylase,decreasinggastriclesionformation.Additionally,catechinincreasesmusclefatigueresistanceandexercisecapacityinvivo.ThiscompoundalsodecreasestumornumberandformationandsuppressesphosphorylationofFAKinanimalmodelsofcolorectalcancer.