LKT/（U00B1）-Equal/E6781/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/（U00B1）-Equal/E6781/100 mg

LKT/（U00B1）-Equal/E6781/100 mg

商品编号： E6781-100mg

品牌： lktlabs

市场价： ¥13440.00

美元价： 8064.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDE6781

CasNo.94105-90-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

EquolisasoyisoflavoneandphytoestrogenusedinveterinarymedicinethatactsasanagoNISTatestrogenreceptors.Equolisthemajormetaboliteofdaidzeinandexhibitsanti-aging,antioxidative,estrogenic,anti-inflammatory,andchemopreventiveactivities.Invitro,equolincreasesexpressionofextracellularmatrixproteinscollagenandelastinaswellasnervegrowthfactor(NGF)anddecreasesexpressionofaginggenesandpro-inflammatorycytokinessuchasmatrixmetalloproteinases1,3,and9(MMP1/3/9),COX-1,IL-6,andIL-1α.Infibroblasts,equolinhibitedROSgenerationandoxidativestress.Inanimalmodels,equolincreasesactivityofcatalase,superoxidedismutase(SOD),glutathioneperoxidase,andglutathionereductase.Additionally,equolinhibitsTNF-αproduction,NF-κBactivation,andIκBkinasedegradationinmacrophages.Thiscompoundincreasesactivationofp53,caspase3,andpoly(ADP)-ribosepolymerase(PARP),increasesexpressionofp21andBax,anddecreasesexpressionofBcl-2,resultinginapoptosisandinhibitionoftumorformationinanimalmodels.

ProductInfo

CasNo.	94105-90-5
Purity	≥98%
Formula	C₁₅H₁₄O₃
FormulaWt.	242.27
ChemicalName	(R,S)-Equol;3,4-Dihydro-3,(4-hydroxyphenyl)-2H-1-benzopyran-7-ol;4",7-Dihydroxyisoflavane
IUPACName	3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol
MeltingPoint	151.0-153.0
Solubility	SolubleinDMSO,ethanol,diluteaqueousbase.Insolubleinwater.
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	E6781MSDSPDF
InfoSheet	E6781InfoSheetPDF
Brochures	NaturalProductsBooklet

References

LephartED.Protectiveeffectsofequolandtheirpolyphenolicisomersagainstdermalaging:microarray/proteinevidencewithclinicalimplicationsanduniquedeliveryintohumanskin.PharmBiol.2013Nov;51(11):1393-400.PMID:23862588.

RichardsonTE,SimpkinsJW.R-andS-equolhaveequivalentcytoprotectiveeffectsinFriedreich"sataxia.BMCPharmacolToxicol.2012Oct22;13:12.PMID:23088310.

ChoiEJ,KimGH.Anticancermechanismofequolin7,12-dimethylbenz(a)anthracene-treatedanimals.IntJOncol.2011Sep;39(3):747-54.PMID:21667019.

MuñozY,GarridoA,ValladaresL.EquolismoreactivethansoyisoflavoneitselftocompeteforbindingtothromboxaneA(2)receptorinhumanplatelets.ThrombRes.2009Mar;123(5):740-4.PMID:18786699.

KangJS,YoonYD,HanMH,etal.Estrogenreceptor-independentinhibitionoftumornecrosisfactor-alphageneexpressionbyphytoestrogenequolismediatedbyblockingnuclearfactor-kappaBactivationinmousemacrophages.BiochemPharmacol.2005Dec19;71(1-2):136-43.PMID:16288994.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂