(-)-Epicatechingallate(ECG)isaflavanol/catechinoriginallyfoundinCamillaandotherplansources;itexhibitsantioxidative,neuromodulatory,anticancer,andanti-inflammatoryactivities.ECGdisplaysagoNISTactivityatcannABInoid1(CB1)receptors.ECGalsoinhibitsexpressionofFLT3anddecreasesphosphorylationofp38MAPK,Akt,andSTAT5inacutemyelogenousleukemia(AML)cells,suppressingcellproliferation.Invitro,thiscompoundinhibitsLPS-orpeptidoglycan-inducedproductionofVEGFandexpressionofCOX-2.
| CasNo. | 1257-08-5 |
|---|---|
| Purity | ≥98% |
| Formula | C22H18O10 |
| FormulaWt. | 442.37 |
| ChemicalName | 3,4,5-Trihydroxybenzoicacid,(2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2-H-1-benzopyran-3-ylester |
| IUPACName | [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl]3,4,5-trihydroxybenzoate |
| Synonym | ECG |
| MeltingPoint | 218°C |
| Solubility | Solubleinwateroralcohol. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E6232MSDSPDF |
|---|---|
| InfoSheet | E6232InfoSheetPDF |
| Brochures | GreenTeaFlyer |
| Brochures | NaturalProductsBooklet |
NakanishiT,MukaiK,HosokawaY,etal.Catechinsinhibitvascularendothelialgrowthfactorproductionandcyclooxygenase-2expressioninhumandentalpulpcells.IntEndodJ.2014May21.[Epubaheadofprint].PMID:24847951.
LyBT,ChiHT,YamagishiM,etal.InhibitionofFLT3expressionbygreenteacatechinsinFLT3mutated-AMLcells.PLoSOne.2013Jun20;8(6):e66378.PMID:23840454.
KorteG,DreiseitelA,SchreierP,etal.Teacatechins"affinityforhumancannabinoidreceptors.Phytomedicine.2010Jan;17(1):19-22.PMID:19897346.
