(E,Z)-4-Hydroxytamoxifenisamixtureofcis-andtrans-isomersof4-hydroxytamoxifen.4-Hydroxytamoxifenistheactivemetaboliteoftamoxifen,aselectiveestrogenreceptormodulator(SERM)thatactsasanagoNISTorantagonistinvarioustissues.4-Hydroxytamoxifenexhibitsanticancerchemotherapeuticactivity,inducingautophagyandvacuoleformationaswellasKRASdegradationinvariouscancercelllines.Incardiacmyocytes,4-hydroxytamoxifendecreasesCa2+amplitude,slowingrelaxationanddecreasingcontractility.
| CasNo. | 68392-35-8 |
|---|---|
| Purity | ≥97% |
| Formula | C26H29NO2 |
| FormulaWt. | 387.51 |
| IUPACName | 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol |
| Synonym | Afimoxifene |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | H9716MSDSPDF |
|---|---|
| InfoSheet | H9716InfoSheetPDF |
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KohliL,KazaN,CoricT,etal.4-HydroxytamoxifeninducesautophagicdeaththroughK-Rasdegradation.CancerRes.2013Jul15;73(14):4395-405.PMID:23722551.
SchwartzJA,ZhongL,Deighton-CollinsS,etal.Mutationstargetedtoapredictedhelixintheextremecarboxyl-terminalregionofthehumanestrogenreceptor-alphaalteritsresponsetoestrADIoland4-hydroxytamoxifen.JBiolChem.2002Apr12;277(15):13202-9.Erratumin:JBiolChem2002Jul5;277(27):24842.PMID:11823467.
