Description
(R)-CR8isananalogofroscovitinethatinhibitscyclin-dependentkinases(CDKs)1/2/3/5/7/9;itdisplaysanticancerandneuroprotectiveactivities.(R)-CR8inducesapoptosisanddownregulatesexpressionofMcl-1inneuroblastomacells.Inchromicmyelogenousleukemia(CML)cells,(R)-CR8inhibitscellcycleprogression.Inanimalmodelsofspinalcordinjury,thiscompounddecreasesneurodegeneration,cognitivedecline,andmicroglialactivation.CR8alsodecreasessensorimotordeficits,cognitivedeficits,andlesionvolumebylimitingcellcycleactivationinanimalmodelsoftraumaticbraininjury.
References
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KabADISV,StoicaBA,LoaneDJ,etal.CR8,anovelinhibitorofCDK,limitsmicroglialactivation,astrocytosis,neuronalloss,andneurologicdysfunctionafterexperimentaltraumaticbraininjury.JCerebBloodFlowMetab.2014Mar;34(3):502-13.PMID:24398934.
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BettayebK,OumataN,EchalierA,etal.CR8,apotentandselective,roscovitine-derivedinhibitorofcyclin-dependentkinases.Oncogene.2008Oct2;27(44):5797-807.PMID:18574471.
