Description
AromaticturmeroneisasesquiterpenefoundinCurcuma(turmeric).Thiscompoundexhibitsanti-inflammatory,anticonvulsant,antifungal,anticancer,andanti-metastaticactivities.AromaticturmeronesuppressesproductionofIL-2andIFN-γinTcells.Inanimalmodelsofchemically-inducedseizures,aromaticturmeronelimitsepilepticactivity.Additionally,turmeronealsoinhibitsgrowthofdermatophytesinvariousmodels.Inbreastcancercells,thiscompounddecreasesphosphorylationofNF-κB,PI3K,andAktandsuppressessignalingofERK1/2,inhibitingcellularmigrationandinvasion.Inothermodels,aromaticturmeronedoesnotinhibittumorgrowthbutdoessuppressthedevelopmentoflymphocyticleukemiainimprovingTandBlymphocyteproliferation.Likeothercompoundsderivedfromturmeric,aromaticturmeronemayindirectlyinhibitEGFR.
References
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