LKT/(S)-CR8/C6801/1 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/(S)-CR8/C6801/1 mg

LKT/(S)-CR8/C6801/1 mg

商品编号： C6801-1mg

品牌： lktlabs

市场价： ¥2080.00

美元价： 1248.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDC6801

CasNo.1084893-56-0

Purity≥99%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

(S)-CR8isananalogofroscovitinethatinhibitscyclin-dependentkinases(CDKs)1/2/3/5/7/9;itdisplaysanticancer,nephroprotective,andneuroprotectiveactivities.CR8inducesapoptosisinvariouscancercellsbysuppressingcellcycleprogression.Inanimalmodelsofspinalcordinjury,thiscompounddecreasesneurodegeneration,cognitivedecline,andmicroglialactivation.CR8alsodecreasessensorimotordeficits,cognitivedeficits,andlesionvolumebylimitingcellcycleactivationinanimalmodelsoftraumaticbraininjury.Inanimalmodelsofpolycystickidneydisease,(S)-CR8decreasesrenalandhepaticcystogenesisandattenuateskidneyfunctiondeclinebysuppressingcellcycleprogressionanddecreasingapoptosis.

ProductInfo

CasNo.	1084893-56-0
Purity	≥99%
Formula	C₂₄H₂₉N₇O
FormulaWt.	431.54
IUPACName	(2S)-2-[(9-Isopropyl-6-{[4-(2-pyridinyl)benzyl]amino}-9H-purin-2-yl)amino]-1-butanol
Synonym	2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine
Solubility	SolubleinDMSOorethanol
Appearance	Whitetooff-whitesolid.

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

InfoSheet	C6801InfoSheetPDF

References

WuJ,ZhaoZ,SABIrzhanovB,etal.Spinalcordinjurycausesbraininflammationassociatedwithcognitiveandaffectivechanges:roleofcellcyclepathways.JNeurosci.2014Aug13;34(33):10989-1006.PMID:25122899.

KabADISV,StoicaBA,LoaneDJ,etal.CR8,anovelinhibitorofCDK,limitsmicroglialactivation,astrocytosis,neuronalloss,andneurologicdysfunctionafterexperimentaltraumaticbraininjury.JCerebBloodFlowMetab.2014Mar;34(3):502-13.PMID:24398934.

BukanovNO,MorenoSE,NatoliTA,etal.CDKinhibitorsR-roscovitineandS-CR8effectivelyblockrenalandhepaticcystogenesisinanorthologousmodelofADPKD.CellCycle.2012Nov1;11(21):4040-6.PMID:23032260.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂