Description
Bradykininisapeptidethatexhibitsnatriuretic,antioxidative,vasodilatory,andpro-angiogenicactivities.BradykininstimulatesbradykininreceptorsandincreasesPLCactivity,decreasingENaCopenprobABIlity,inhibitingdistalnephronNa+transport,andinducingnatriuresis.Invitro,bradykinindecreasesH2O2-inducedsenescence,increasesactivityofsuperoxidedismutase(SOD),andsuppressesDNAdamage,ROSproduction,andNADPHoxidaseactivity.Additionally,bradykininincreasesexpressionofVEGFandpromotestubeformationinprostatecancercells.
References
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YuHS,WangSW,ChangAC,etal.Bradykininpromotesvascularendothelialgrowthfactorexpressionandincreasesangiogenesisinhumanprostatecancercells.BiochemPharmacol.2014Jan15;87(2):243-53.PMID:24225154.
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