Description
Bombesinisagastrin-releasingpeptideanalogthatbindsbombesinandGRPreceptors.Derivativesofbombesinarecurrentlyunderinvestigationascancerimagingtools,asbombesinreceptorsareoftenoverexpressedintumortissues.Bombesinitselfexhibitsneuromodulatory,hepatoprotective,cardiomodulatory,andvasoconstrictiveactivities.BombesinincreasesthefrequencyandamplitudeofIPSCsintheentorhinalcortex,likelyduetoCa2+-mediatedincreasesinGABArelease.Inanimalmodelsofliverdisease,bombesinincreasesproliferationofovalcellsandhepatocytes,increaseslevelsofglutathione,anddecreasesportalendotoxemia.Bombesinalsoexhibitspressor-likeeffects,increasingmeanarterialpressure,bloodpressure,andheartrate.
References
ZhangHP,XiaoZ,CilzNI,etal.BombesinfacilitatesGABAergictransmissionanddepressesepileptiformactivityintheentorhinalcortex.Hippocampus.2014Jan;24(1):21-31.PMID:23966303.
OkarviSM,JammazIA.Preparationandevaluationofbombesinpeptidederivativesaspotentialtumorimagingagents:effectsofstructureandcompositionofaminoacidsequenceoninvitroandinvivocharacteristics.NuclMedBiol.2012Aug;39(6):795-804.PMID:22381782.
AssimakopoulosSF,TsamandasAC,AlexandrisIH,etal.Stimulationofovalcellandhepatocyteproliferationbyexogenousbombesinandneurotensininpartiallyhepatectomizedrats.WorldJGastrointestPathophysiol.2011Dec15;2(6):146-54.PMID:22180848.
ZogovicB,PilowskyPM.Intrathecalbombesinissympathoexcitatoryandpressorinrat.AmJPhysiolRegulIntegrCompPhysiol.2011Nov;301(5):R1486-94.PMID:21849634.
![LKT/[TYR4]-BOMBESIN/B5649/2 mg](https://www.ebiomall.cn/images/lktlabs/b5649.png)
