LKT/2,3,5,6-川芎嗪/T1778/25克-免疫在线蚂蚁淘旗下平台

商品详细LKT/2,3,5,6-川芎嗪/T1778/25克

LKT/2,3,5,6-川芎嗪/T1778/25克

商品编号： T1778-25g

品牌： lktlabs

市场价： ¥1040.00

美元价： 624.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDT1778

CasNo.1124-11-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

TetramethylpyrazineisadihydropyrazinefoundinLigusticumwalliichithatexhibitsneuromodulatory,antioxidative,cognitionenhancing,nephroprotective,antifibrotic,anti-inflammatory,andanticancerchemotherapeuticactivities.ThiscompoundalsoinhibitsPDE10A2andactsasanantagoNISTatadenosine2Aand2Breceptors.Invitro,tetramethylpyrazinepromotesneuralProgenitorcellmigrationandincreasesPI3K,PKC,andERKsignaling.TetramethylpyrazinealsoinducesneuroblastomadifferentiationbytargetingTopoisomeraseIiβ(topoIIβ).Inanimalmodelsofchronicalcoholicencephalopathy,Tetramethylpyrazineimproveslearningandmemory.Additionally,thiscompoundinhibitsarsenic-inducedproductionofROSandpreventsapoptosisandmitochondrialdysfunctioninkidneycells.Tetramethylpyrazinealsoamelioratesoxidativeinjuryinducedbymethotrexate.Invitro,thiscompoundinhibitsproliferationofhepaticstellatecells.Inanimalmodelsofhepatocellularcarcinoma,tetramethylpyrazineinhibitstumordevelopmentandgrowthandinducescellcyclearrestandapoptosis.

ProductInfo

CasNo.	1124-11-4
Purity	≥98%
Formula	C₈H₁₂N₂
FormulaWt.	136.20
IUPACName	Tetramethylpyrazine
Synonym	Tetramethylpyrazine;Ligustrazine

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	T1778InfoSheetPDF

References

YanYX,ZhaoJX,HanS,etal.TetramethylpyrazineinducesSH-SY5YcelldifferentiationtowardtheneuronalphenotypethroughactivationofthePI3K/Akt/Sp1/TopoIIβpathway.EurJCellBiol.2015Dec;94(12):626-41.PMID:26518113.

KongX,ZhongM,SuX,etal.TetramethylpyrazinePromotesMigrationofNeuralPrecursorCellsviaActivatingthePhosphatidylinositol3-KinasePathway.MolNeurobiol.2015Nov28.[Epubaheadofprint].PMID:26614511.

ZhangB,LuC,BaiM,etal.Tetramethylpyrazineidentifiedbynetworkpharmacologyapproachesamelioratesmethotrexate-inducedoxidativeorganinjury.JEthnopharmacol.2015Oct1.[Epubaheadofprint].PMID:26435225.

LiH,YangX,ShiW,etal.ProtectiveEffectsofTetramethylpyrazineonCerebrovascularRegulationsinRatswithChronicAlcoholicEncephalopathy.BiomedEnvironSci.2015Sep;28(9):691-5.PMID:26464259.

GongX,IvanovVN,HeiTK.2,3,5,6-Tetramethylpyrazine(TMP)down-regulatedarsenic-inducedhemeoxygenase-1andARS2expressionbyinhibitingNrf2,NF-κB,AP-1andMAPKpathwaysinhumanproximaltubularcells.ArchToxicol.2015Sep24.[Epubaheadofprint].PMID:26404762.

HuJ,CaoG,WuX,etal.TetramethylpyrazineInhibitsActivationofHepaticStellateCellsthroughHedgehogSignalingPathwaysInVitro.BiomedResInt.2015;2015:603067.PMID:26380286.

ZhaoS,ZhangY,ChenQ,etal.Amodified"double-hit"inducedacutelunginjurymodelinratsandprotectiveeffectsoftetramethylpyrazineontheinjuryviaRho/ROCKpathway.IntJClinExpPathol.2015May1;8(5):4581-7.PMID:26191148.

CaoJ,MiaoQ,ZhangJ,etal.INHIBITORYEFFECTOFTETRAMETHYLPYRAZINEONHEPATOCELLULARCARCINOMA:POSSIBLEROLEOFAPOPTOSISANDCELLCYCLEARREST.JBiolRegulHomeostAgents.2015Apr-Jun;29(2):297-306.PMID:26122217.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂