Description
3-Aminobenzamine is an inhibitor of poly(ADP)-ribosyl polymerase (PARP) that exhibits cytoprotective, anti-atherosclerotic, and anticancer activities. 3-Aminobenzamide prevents UV-induced cell death in vitro and inhibits TGF-β1-induced phosphorylation of Smad3 in other cellular models. In vivo, this compound inhibits production of inflammatory cytokines, suppresses PARP activation, and decreases atherosclerotic lesion size. Additionally, 3-aminobenzamide induces G1 phase cell cycle arrest, downregulates expression of cyclin D1, β-catenin, c-Jun, c-Myc, and Id2, upregulates expression of p21 and genes involved in differentiation, and induces differentiation in osteosarcoma cells.
References
Lakatos P, Szabó É, Hegedűs C, et al. 3-Aminobenzamide protects primary human keratinocytes from UV-induced cell death by a poly(ADP-ribosyl)ation independent mechanism. Biochim Biophys Acta. 2013 Mar;1833(3):743-51. PMID: 23246565.
Huang D, Wang Y, Wang L, et al. Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell. PLoS One. 2011;6(10):e27123. PMID: 22073128.
Xie JJ, Yu X, Liao YH, et al. Poly (ADP-Ribose) polymerase inhibition attenuates atherosclerotic plaque development in ApoE-/- mice with hyperhomocysteinemia. J Atheroscler Thromb. 2009 Oct;16(5):641-53. PMID: 19776495.
De Blasio A, Messina C, Santulli A, et al. Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. FEBS Lett. 2005 Jan 31;579(3):615-20. PMID: 15670817.
