Description
4-O-MethylhonokiolisamajorbioactiveconstituentofMagnoliaofficinalisstembark.InastudywithC57BK/6Jmice,4-O-methylhonokiolpreventedhigh-fat-dietinducedobesityandinsulinresistance,inadditiontorestoringimpairedcardiacinsulinsignaling.InanotherstudyusingfemaleRjOrlmice,4-O-methylhonokiolwasshowntoactasacentralnervoussystempenetratingsubstrate-specificinhibitorofCOX-2andasaCB2receptoragoNIST.FurThermore,inhigh-riskHPV-16genotypeSiHacells,treatmentwith4-O-methylhonokiolsuppressedthePI3K/Aktsignalingpathwaytherebyreducingthesurvivalofthecells.4-O-methylhonokiolhasalsoshownseveralotherBIOLOGicalactivitiesincludinganti-inflammatory,antithrombotic,anti-anxiety,antimicrobial,andanti-HIVactivities.
References
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ZhangZ,ChenJ,ZhouS,etal.Magnoliabioactiveconstituent4-O-methylhonokiolpreventstheimpairmentofcardiacinsulinsignalingandthecardiacpathogenesisinhigh-fatdiet-inducedobesemice.IntJBiolSci.2015Jun5;11(8):879-891.PMID:26157343.
ChiccaA,GachetMS,PetrucciV,etal.4’-O-Methylhonokiolincreaseslevelsof2-arachidonoylglycerolinmousebrainviaselectiveinhibitionofitsCOX-2-mediatedoxygenation.JNeuroinflammation.2015May13;12:89.PMID:25962384.
HanJY,AhnSY,YooJH,etal.Alleviationofkainicacid-inducedbrainbarrierdysfunctionby4-O-methylhonokiolininvitroandinvivomodels.BiomedResInt.2015;2015:893163.PMID:25688368.
HyunS,KimMS,SongYS,etal.Peroxisomeproliferator-activatedreceptor-gammaagonist4-O-methylhonokiolinducesapoptosisbytriggeringtheintrinsicapoptosispathwayandinhibitingthePI3K/AktsurvivalpathwayinSiHahumancervicalcancercells.JMicrobiolBiotechnol.2015Mar;25(3):334-342.PMID:25563418.
