5,6-DehydrokawainisakavalactoneoriginallyfoundinPipermethysticum(kavaplant)andAlpiniathatexhibitsneuroprotectiveandantithromboticactivities.5,6-DehydrokawaininhibitsaggregationandATPreleaseofplateletsaswellasformationofthromboxaneB2(TxB2).Additionally,thiscompoundpreventsH2O2-inducedtoxicity,decreasingreleaseoflactatedehydrogenase,activationofcaspase3,andoxidativestressinneurons.
| CasNo. | 1952-41-6 |
|---|---|
| Purity | ≥98% |
| Formula | C14H12O3 |
| FormulaWt. | 228.25 |
| IUPACName | 4-methoxy-6-[(E)-2-phenylethenyl]pyran-2-one |
| MeltingPoint | 138-140°C |
| Appearance | White/OffWhitePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | D1628InfoSheetPDF |
|---|
RaoYK,ShihHN,LeeYC,etal.PurificationofkavalactonesfromAlpiniazerumbetandtheirprotectiveactionsagainsthydrogenperoxide-inducedcytotoxicityinPC12cells.JBiosciBioeng.2014Jun11.[Epubaheadofprint].PMID:24929995.
TengCM,HsuSY,LinCH,etal.AntiplateletactionofdehydrokawainderivativesisolatedfromAlpiniaspeciosarhizoma.ChinJPhysiol.1990;33(1):41-8.PMID:2376215.
