AngiotensinII(ATII)isapeptideproducedfromATIbyangiotensin-converting-enzyme(ACE).ATIIbindstheATIItype1(AT1)receptor,stimulatingGPCRsinvascularsmoothmusclecellsandincreasingintracellularCa2+levels;thisresultsincontractionandvasoconstriction,increasingbloodpressure.ATIIalsoactsattheNa+/H+exchangerintheproximaltubulesofthekidney.Here,ATIIincreasesreabsorptionofNa+andHCO3-andexcretionofH+,increasingbloodvolumeandpHandfurtherincreasingbloodpressure.
| CasNo. | 67724-27-0 |
|---|---|
| Purity | ≥95% |
| Formula | C46H74N13O10 |
| FormulaWt. | 968.1 |
| IUPACName | 2-[[1-[2-[[2-[[2-[[2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoicacid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A5282MSDSPDF |
|---|---|
| InfoSheet | A5282InfoSheetPDF |
DeGiustiVC,CiancioMC,OrlowskiA,etal.Modulationofthecardiacsodium/bicarbonatecotransporterbythereninangiotensinaldosteronesystem:pathophysiologicalconsequences.FrontPhysiol.2014Jan17;4:411.PMID:24478712.
MoonJY.RecentUpdateofRenin-angiotensin-aldosteroneSysteminthePathogenesisofHypertension.ElectrolyteBloodPress.2013Dec;11(2):41-45.PMID:24627703.
![LKT/[SAR1-ILE8]-血管紧张素II/A5282/25mg](https://www.ebiomall.cn/images/lktlabs/a5282.png)
