Description
Thiscompoundisasyntheticderivativeof6-methylsulfinyl-hexaneisothiocyanate,whichwasinitiallyproducedbyWasABIa;itisananalogofsulforaphane.Thisisothiocyanate(ITC)exhibitsanticancerchemotherapeutic,anti-inflammatory,antioxidative,andneuroprotectiveactivities.ThiscompoundinhibitsSOX2signaling,inducesG2/Mphasecellcyclearrest,andsuppressescellviabilityinpancreaticcancercells.Thiscompoundalsodecreasestumorvolumeandweightinanimalmodelsofbreastcancer.Additionally,thisITCinhibitsexpressionofCOX-2,iNOS,andinflammatorycytokinesinmacrophages.Instriatalcultures,thiscompoundactivatesNrf2andincreaseslevelsofhemeoxygenase1(HO-1),suppressingoxidativestress.ThisisothiocyanatealsoinhibitsGSK-3β.
References
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ChenYJ,HuangYC,TsaiTH,etal.EffectofWasabiComponent6-(Methylsulfinyl)hexylIsothiocyanateandDerivativesonHumanPancreaticCancerCells.EvidBasedComplementAlternatMed.2014;2014:494739.PMID:24575144.
UtoT,HouDX,MorinagaO,etal.MolecularMechanismsUnderlyingAnti-InflammatoryActionsof6-(Methylsulfinyl)hexylIsothiocyanateDerivedfromWasabi(Wasabiajaponica).AdvPharmacolSci.2012;2012:614046.PMID:22927840.
MizunoK,KumeT,MutoC,etal.GlutathionebiosynthesisviaactivationofthenuclearfactorE2-relatedfactor2(Nrf2)--antioxidant-responseelement(ARE)pathwayisessentialforneuroprotectiveeffectsofsulforaphaneand6-(methylsulfinyl)hexylisothiocyanate.JPharmacolSci.2011;115(3):320-8.PMID:21358121.
YoshidaJ,NomuraS,NishizawaN,etal.Glycogensynthasekinase-3βinhibitionof6-(methylsulfinyl)hexylisothiocyanatederivedfromwasabi(WasabiajaponicaMatsum).BiosciBiotechnolBiochem.2011;75(1):136-9.PMID:21228474.
