Description
Neurotensinisatridecapeptidethatexhibitsantinociceptive,pro-inflammatory,andgastrointestinalmotilitymodulatingactivities.Neurotensininducescontractionsinsmoothmusclecells,playingaroleinregulatingdigestiveactivityinvitroandinvivo.Additionally,neurotensininducesintracellularCa2+release,activatingnon-selectivecationchannelsandalteringpacemakercurrentsinvolvedingastrointestinalandcolonicmotility.Inanimalmodels,neurotensindisplayssympatho-inhibitoryactivity,decreasesbloodpressureandheartrate.Neurotensinexertsitsactionsthroughactivationofneurotensinreceptors;activationofthesereceptorsalsostimulatesorexinneurons,suggestingaroleforneurotensininmediationofreward,feeding,andwakefulness.
References
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