LKT/[TYR8]-物质P/S8013/5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/[TYR8]-物质P/S8013/5 mg

LKT/[TYR8]-物质P/S8013/5 mg

商品编号： S8013-5mg

品牌： lktlabs

市场价： ¥6040.00

美元价： 3624.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDS8013

CasNo.55614-10-3

Purity≥95%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

SubstanceP(SP)isanendogenoustachykininneuropeptidethatisinvolvedininflammatory,pain,andstresssignaling;itexhibitsneuroprotective,cognitionenhancing,andgastrointestinalmotilitymodulatingactivities.SPexhibitsneuroprotectiveactivitybydecreasingexpressionofKv1.4K+channelsintransgenicanimalmodelsofAlzheimer’sdiseaseandimprovingcognitiveperformanceintheMorriswatermazetask.SPisthenaturalligandfortheneurokinin-1(NK1)receptor.Invariousanimalmodels,SPmodulatesopioidsignaling,inducesgastricmucosalprotection,andinhibitsretinalapoptosis.SPalsopreventshyperoxia-inducedlungdamage,decreasinglevelsofmalondialdehydeandincreasinglevelsofsuperoxidedismutase(SOD);thisactivitymayberegulatedthroughSHHsignaling.Inmelanomacells,SPdecreaseslevelsoftyrosinaseandmelanin,inhibitingmelanogenesis.Inothercellularmodels,SPincreasestheviABIlityandproliferationofosteoblastsandpromotesgapjunctionintracellularcommunication.

ProductInfo

CasNo.	55614-10-3
Purity	≥95%
Formula	C₆₃H₉₈N₁₈O₁₄S
FormulaWt.	1363.66
IUPACName	2-[[1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[5-amino-1-[[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	S8013InfoSheetPDF

References

YangL,LiuC,DangH,etal.SubstancePattenuateshyperoxiainducedlunginjuryinneonatalrats.MolMedRep.2014Feb;9(2):595-9.PMID:24247295.

CampolongoP,RatanoP,CiottiMT,etal.SystemicadmiNISTrationofsubstancePrecoversbetaamyloid-inducedcognitivedeficitsinrat:involvementofKvpotassiumchannels.PLoSOne.2013Nov12;8(11):e78036.PMID:24265678.

YangJH,GuoZ,ZhangT,etal.RestorationofendogenoussubstancePisassociatedwithinhibitionofapoptosisofretinalcellsindiabeticrats.RegulPept.2013Nov10;187:12-6.PMID:24045094.

MaW,ZhangX,ShiS,etal.Neuropeptidesstimulatehumanosteoblastactivityandpromotegapjunctionalintercellularcommunication.Neuropeptides.2013Jun;47(3):179-86.PMID:23726661.

BrancatiSB,ZádoriZS,NémethJ,etal.SubstancePinducesgastricmucosalprotectionatsupraspinallevelviaincreasingthelevelofendomorphin-2inrats.BrainResBull.2013Feb;91:38-45.PMID:23328537.

PingF,ShangJ,ZhouJ,etal.Activationofneurokinin-1receptorbysubstancePinhibitsmelanogenesisinB16-F10melanomacells.IntJBiochemCellBiol.2012Dec;44(12):2342-8.PMID:23041339.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂