Description
GinsenosideRg3isatriterpenesaponinfoundinPanaxthatexhibitsneuromodulatory,cognitionenhancing,anti-inflammatory,antioxidative,anti-angiogenic,andanticanceractivities.GinsenosideRg3activatesKCNQ1/Kv7.1K+channelsandtheγ2subunitofGABA-Areceptorsandinhibitstheα10subunitofnicotinicacetylcholinereceptors(nAChRs).Inanimalmodels,ginsenosideRg3decreasesexpressionofTNF-α,IL-1β,andCOX-2inthehippocampus,improvinglearningandmemorydeficits.Invitro,ginsenosideRg3preventsLPS-inducedupregulationofTNF-α,IL-1β,andIL-6levelsanddecreasesactivationofmicroglia.Inotheranimalmodels,thiscompounddecreasesoxidativestressbyincreasingactivityofcatalase,superoxidedismutase(SOD),andlysozymeanddecreasinglevelsofNOandmalondialdehyde.GinsenosideRg3alsoexhibitsanti-angiogenicbenefit,inhibitingVEGF/p38/ERKsignalingtoinhibittubularformationandmigrationofendothelialProgenitorcells.Inosteosarcomacells,thiscompoundincreasedDNAdamagebyinducingstrandbreaksintodouble-strandedDNA.
References
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ParkSM,ChoiMS,SohnNW,etal.GinsenosideRg3attenuatesmicrogliaactivationfollowingsystemiclipopolysaccharidetreatmentinmice.BiolPharmBull.2012;35(9):1546-52.PMID:22975507.
WeiX,SuF,SuX,etal.StereospecificantioxidanteffectsofginsenosideRg3onoxidativestressinducedbycyclophosphamideinmice.Fitoterapia.2012Jun;83(4):636-42.PMID:22310172.
KimJW,JungSY,KwonYH,etal.GinsenosideRg3attenuatestumorangiogenesisviainhibitingbioactivitiesofendothelialprogenitorcells.CancerBiolTher.2012May;13(7):504-15.PMID:22406998.
