25-hydroxyvitaminD2(25-OHD2)isametabolicproductofergocalciferol,orvitaminD2,anexogenouslyproducedvitaminDdietarysupplement.25-OHD2restoresbonemineralizationinvitaminD-deficientmodelsandalsoregulatesCa2+homeostasisasadownstreameffectofthevitaminDsignalingcascade.25-OHD3bindstothevitaminDreceptor(VDR)butwithloweraffinitythat25-hydroxyvitaminD3(25-OHD3).Potentialmechanismsremainunknown,butlowlevelsof25-OHD2areassociatedwithAlzheimer’sdiseaseinsomestudies.
| CasNo. | 21343-40-8 |
|---|---|
| Purity | ≥90% |
| Formula | C28H44O2 |
| FormulaWt. | 412.65 |
| ChemicalName | (E,3S,6S)-6-[(1R,3aR,4E,7aS)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2,3-dimethyl-hept-4-en-2-ol |
| IUPACName | (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol |
| MeltingPoint | 88.0-95.0°C |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | H9814InfoSheetPDF |
|---|
ShahI,PetrocziA,TabetN,etal.Low25OHvitaminD2levelsfoundinuntreatedAlzheimer"spatients,comparedtoacetylcholinesterase-inhibitortreatedandcontrols.CurrAlzheimerRes.2012Nov;9(9):1069-76.PMID:22876849.
HoughtonLA,ViethR.Thecaseagainstergocalciferol(vitaminD2)asavitaminsupplement.AmJClinNutr.2006Oct;84(4):694-7.PMID:17023693.
