Geldanamycinderivative17-AAGisaninhibitorofheatshockprotein90(HSP90)thatexhibitsanti-inflammatory,anticancerchemotherapeutic,andantiviralactivities.Inendothelialcells,17-AAGinducesdegradationofIκBα,attenuatingNF-κBactivation.17-AAGinducesBax-dependentapoptosisinavarietyofcancermodels,bothinvitroaswellasinvivo.Additionally,17-AAGinhibitsreplicationofhumancytomegalovirus.
| CasNo. | 75747-14-7 |
|---|---|
| Purity | ≥97% |
| Formula | C31H43N3O8 |
| FormulaWt. | 585.69 |
| IUPACName | [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azABIcyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl]carbamate |
| Synonym | 17-(Allylamino)-17-desmethoxy-geldanamycin;allylaminogeldanamycin;17-AAG;telatinib. |
| MeltingPoint | 200-205°C |
| Solubility | SolubleinDMSOormethanol. |
| Appearance | Purplepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A0025MSDSPDF |
|---|---|
| InfoSheet | A0025InfoSheetPDF |
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PowersMV,ValentiM,MirandaS,etal.ModeofcelldeathinducedbytheHSP90inhibitor17-AAG(tanespimycin)isdependentontheexpressionofpro-apoptoticBAX.Oncotarget.2013Nov;4(11):1963-75.PMID:24185264.
EversDL,ChaoCF,ZhangZ,etal.17-allylamino-17-(demethoxy)geldanamycin(17-AAG)isapotentandeffectiveinhibitorofhumancytomegalovirusreplicationinprimaryfibroblastcells.ArchVirol.2012Oct;157(10):1971-4.PMID:22711259.
GloesenkampC,NitzscheB,LimAR,etal.Heatshockprotein90isapromisingtargetforeffectivegrowthinhibitionofgastrointestinalneuroendocrinetumors.IntJOncol.2012May;40(5):1659-67.PMID:22246317.
