2’,3’-Dideoxyinosineisapurine(guanosine)nucleosideanalogthatexhibitsantiviralactivitythroughthedirectinhibitionofreversetranscriptase.2’,3’-Dideoxyinosineactsasachainterminatorandisonecomponentofhighlyactiveantiretroviraltherapy(HAART)regimensusedinthetreatmentofHIVandAIDS.2’,3’-Dideoxyinosinealsoinhibitsthehumoralimmuneresponseinvivo,targetingBlymphocytes.
| CasNo. | 69655-05-6 |
|---|---|
| Purity | ≥98% |
| Formula | C10H12N4O3 |
| FormulaWt. | 236.23 |
| ChemicalName | 2",3"-Dideoxyinosine |
| IUPACName | 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one |
| Synonym | Didanosine;Dideoxyinosine;ddI;ddIno;Videx |
| MeltingPoint | 160-163°C |
| Solubility | SolubleinDMSO,polyethyleneglycol. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | D3214MSDSPDF |
|---|---|
| InfoSheet | D3214InfoSheetPDF |
| Brochures | AntiviralsBooklet |
RiberaE,TusetM,MartínM,etal.Characteristicsofantiretroviraldrugs.EnfermInfeccMicrobiolClin.2011May;29(5):362-91.PMID:21531048.
PhillipsKE,MunsonAE.2"3"-DideoxyinosineinhibitsthehumoralimmuneresponseinfemaleB6C3F1micebytargetingtheBlymphocyte.ToxicolApplPharmacol.1997Aug;145(2):260-7.PMID:9266798.
