LKT/5-AZA-2U2032-DEOXYCYTIDINE/A9603/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/5-AZA-2U2032-DEOXYCYTIDINE/A9603/10 mg

LKT/5-AZA-2U2032-DEOXYCYTIDINE/A9603/10 mg

商品编号： A9603-10mg

品牌： lktlabs

市场价： ¥2080.00

美元价： 1248.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDA9603

CasNo.2353-33-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

DecitABIneisadeoxycytidineanalogthatisincorporatedintoDNA,inhibitingDNAmethyltransferase(DNMT1/3A/3B)activity.Thisdemethylatingagentisclinicallyusedtotreatmyelodysplasticsyndromes.Decitabine’sinhibitionofDNAmethyltransferasemaybemodulatedbyPKC.Decitabineexhibitsanticancerchemotherapeutic,immunomodulatory,andneurotoxicactivities.Incellularmodelsofacutemyelogenousleukemia(ALL),decitabinedemethylationpreventscancercellinactivationofTRAILsignaling,increasingapoptosisandcelldeath.Invivo,decitabinestimulatesincreasesincancertestisantigen-specificcytotoxic(CD8+)Tcellactivity.Indopaminergicneurons,thiscompoundinducesapoptosisandupregulationoftyrosinehydroxylaseandα-synuclein,suggestingcomplicationsforuseinsubjectswithParkinson’sdisease.DecitabinealsoinhibitsreplicationofHIVincellularmodelswithoutdisplayingcytotoxicity.Additionally,thiscompoundshowsbenefitinthetreatmentofsickle-cellanemiathroughitsstimulationoffetalhemoglobinproduction.

ProductInfo

CasNo.	2353-33-5
Purity	≥98%
Formula	C₈H₁₂N₄O₄
FormulaWt.	228.21
IUPACName	4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
Synonym	2"-Deoxy-5-azacytidine,4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one,Decitabine
Solubility	aceticacid:water(1:1):50mg/mL
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	A9603MSDSPDF
InfoSheet	A9603InfoSheetPDF

References

ZhouJH,YaoYS,WangLX,etal.DemethylatingagentdecitabineinducesautologouscancertestisantigenspecificcytotoxicTlymphocytesinvivo.ChinMedJ(Engl).2013Dec;126(23):4552-6.PMID:24286424.

WangY,WangX,LiR,etal.ADNAmethyltransferaseinhibitor,5-aza-2"-deoxycytidine,exacerbatesneurotoxicityandupregulatesParkinson"sdisease-relatedgenesindopaminergicneurons.CNSNeurosciTher.2013Mar;19(3):183-90.PMID:23441691.

SonciniM,SantoroF,GutierrezA,etal.TheDNAdemethylatingagentdecitabineactivatestheTRAILpathwayandinducesapoptosisinacutemyeloidleukemia.BiochimBiophysActa.2013Jan;1832(1):114-20.PMID:23046813.

DattaJ,GhoshalK,MotiwalaT,etal.NovelInsightsintotheMolecularMechanismofActionofDNAHypomethylatingAgents:RoleofProteinKinaseCδinDecitabine-InducedDegradationofDNAMethyltransferase1.GenesCancer.2012Jan;3(1):71-81.PMID:22893792.

SabaHI.Decitabineinthetreatmentofmyelodysplasticsyndromes.TherClinRiskManag.2007Oct;3(5):807-17.PMID:18473005.

MomparlerRL.Pharmacologyof5-Aza-2"-deoxycytidine(decitabine).SeminHematol.2005Jul;42(3Suppl2):S9-16.PMID:16015507.

BouchardJ,WalkerMC,LeclercJM,etal.5-azacytidineand5-azadeoxycytidineinhibithumanimmunodeficiencyvirustype1replicationinvitro.AntimicrobAgentsChemother.1990Feb;34(2):206-9.PMID:1691617.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂