5-Fluorouracil(5-FU)isanantimetabolitepyrimidineanalogthatexhibitsanticancerchemotherapeuticactivity;itinhibitsthymidylatesynthase,preventingthymidinesynthesis.5-FUisclinicallyusedtotreatvariouscancersandisoftenco-admiNISTeredwithotherchemotherapeuticstodecreaseitsperipheralcytotoxicity.
| CasNo. | 51-21-8 |
|---|---|
| Purity | ≥98% |
| Formula | C4H3FN2O2 |
| FormulaWt. | 130.08 |
| ChemicalName | 5-Fluoro-2,4(1H,3H)-pyrimidinedione |
| IUPACName | 5-fluoro-1H-pyrimidine-2,4-dione |
| Synonym | Fluorouracil;5-FU;2,4-dioxo-5-fluoropyrimidine |
| MeltingPoint | 282-283°C(dec.) |
| Solubility | Slightlysolubleinwater(12mg/mL). |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | F4480MSDSPDF |
|---|---|
| InfoSheet | F4480InfoSheetPDF |
PapanastasopoulosP,StebbingJ.Molecularbasisof5-fluorouracil-relatedtoxicity:lessonsfromclinicalpractice.AnticancerRes.2014Apr;34(4):1531-5.PMID:24692679.
LongleyDB,HarkinDP,JohnstonPG.5-fluorouracil:mechanismsofactionandclinicalstrategies.NatRevCancer.2003May;3(5):330-8.PMID:12724731.
