Description
Abacavir is a guanosine nucleoside analog reverse transcriptase inhibitor (NRTI) that is clinically used to treat HIV infection. Abacavir exhibits antiviral activity. This compound also inhibits guanylyl cyclase and telomerase activity.
Abacavir is a guanosine nucleoside analog reverse transcriptase inhibitor (NRTI) that is clinically used to treat HIV infection. Abacavir exhibits antiviral activity. This compound also inhibits guanylyl cyclase and telomerase activity.
Cas No. | 188062-50-2 |
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Purity | ≥98% |
Formula | (C14H18N6O)2 • H2O4S |
Formula Wt. | 670.75 |
IUPAC Name | [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol;sulfuric acid |
Synonym | Abacavir hemisulfate |
Appearance | White to off white powder |
Store Temp | Ambient |
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Ship Temp | Ambient |
Info Sheet | A0402 Info Sheet PDF |
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Brochures | Antivirals Booklet |
Leeansyah E, Cameron PU, Solomon A, et al. Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging. J Infect Dis. 2013 Apr;207(7):1157-65. PMID: 23303810.
Baum PD, Sullam PM, Stoddart CA, et al. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. AIDS. 2011 Nov 28;25(18):2243-8. PMID: 21941165.
Ribera E, Tuset M, Martín M, et al. Characteristics of antiretroviral drugs. Enferm Infecc Microbiol Clin. 2011 May;29(5):362-91. PMID: 21531048.