LKT/放线菌素/A0977/5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/放线菌素/A0977/5 mg

LKT/放线菌素/A0977/5 mg

商品编号： A0977-5mg

品牌： lktlabs

市场价： ¥1940.00

美元价： 1164.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID A0977

Cas No. 50-76-0

Purity ≥98%

Description
Product Info
Shipping and Storage
Downloads
References

Description

Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA, preventing chain elongation and inhibiting RNA polymerase and topoisomerase activity. In cellular and animal models of chronic lymphocytic leukemia (CLL), this compound downregulates expression of Bcl-2 and Mcl-1, induces apoptosis, inhibits cellular proliferation, and decreases tumor burden.

Product Info

Cas No.	50-76-0
Purity	≥98%
Formula	C₆₂H₈₆N₁₂O₁₆
Formula Wt.	1255.50
IUPAC Name	2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Synonym	Actinomycin D; Meractinomycin; Dactinomycin
Melting Point	245-255°C (dec.)
Solubility	Soluble in ethanol, propylene glycol, water + glycol mixture. Soluble in DMSO (50mg/mL) and methanol (10mg/mL).
Appearance	Salmon Pink Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	A0977 MSDS PDF
Info Sheet	A0977 Info Sheet PDF

References

Merkel O, Wacht N, Sifft E, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. 2012 Dec;26(12):2508-16. PMID: 22743622.

Koba M, Konopa J. Actinomycin D and its mechanisms of action. Postepy Hig Med Dosw (Online). 2005;59:290-8. PMID: 15995596.

Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. PMID: 2410919.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂