LKT/(U2212)-HUPERZINE A/H8162/5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/(U2212)-HUPERZINE A/H8162/5 mg

LKT/(U2212)-HUPERZINE A/H8162/5 mg

商品编号： H8162-5mg

品牌： lktlabs

市场价： ¥8980.00

美元价： 5388.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDH8162

CasNo.102518-79-6

Purity≥97%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

HuperzineA(HupA)isasesquiterpenealkaloidderivedfromthefir-likemossHuperziaserrata;itexhibitsanticonvulsant/antiepileptic,neuromodulatory,cognitionenhancing,neuroprotective,andantinociceptiveactivities.HupAactsasareversIBLe,selectiveacetylcholinesterase(AChE)inhibitorandisbeingexploredinclinicaltrialsasapotentialtreatmentforAlzheimer’sDisease.SeveralstudieshaveshownHupAtoimprovecognition,memory,mood,and/ordailyactivitiesatarangeofdoses.Additionally,HupA’scomparativelylong-lastingbindingofAChEisprotectiveagainstorganophosphate-inducedseizureandstatusepilepticus.Incellularandanimalmodels,thiscompoundexhibitsnon-competitive,reversibleantagoNISTactivityatNMDAreceptors.HupAisalsounderexaminationasapotentialnon-dependence-inducingantinociceptive,asitblockschemical,thermal,andmechanicalpainstimulationinvivo.

ProductInfo

CasNo.	102518-79-6
Purity	≥97%
Formula	C₁₅H₁₈N₂O
FormulaWt.	242.32
ChemicalName	1-amino-13-ethylidene-11-methyl-6-aza-tricyclo-[7.3.1.02,7]trideca-2(7),3,10-trien-5-one
Synonym	HupA
MeltingPoint	214-215°C
Solubility	SolubleinDMSO,ethanol,methanol,andaqueousacids.
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

InfoSheet	H8162InfoSheetPDF

References

YuD,ThakorDK,HanI,etal.AlleviationofchronicpainfollowingratspinalcordcompressioninjurywithmultimodalactionsofhuperzineA.ProcNatlAcadSciUSA.2013Feb19;110(8):E746-55.PMID:23386718.

RafiiMS,WalshS,LittleJT,etal.AphaseIItrialofhuperzineAinmildtomoderateAlzheimerdisease.Neurology.2011Apr19;76(16):1389-94.doi:PMID:21502597.

ParkP,SchachterS,YakshT.IntrathecalhuperzineAincreasesthermalescapelatencyanddecreasesflinchingbehaviorintheformalintestinrats.NeurosciLett.2010Feb5;470(1):6-9.PMID:20026382.

ZhangZ,WangX,ChenQ,etal.ClinicalefficacyandsafetyofhuperzineAlphaintreatmentofmildtomoderateAlzheimerdisease,aplacebo-controlled,double-blind,randomizedtrial.ZhonghuaYiXueZaZhi.2002Jul25;82(14):941-4.PMID:12181083.

GordonRK,NigamSV,WeitzJA,etal.TheNMDAreceptorionchannel:asiteforbindingofHuperzineA.JApplToxicol.2001Dec;21Suppl1:S47-51.PMID:11920920.

CampsP,ElAchabR,MorralJ,etal.Newtacrine-huperzineAhybrids(huprines):highlypotenttight-bindingacetylcholinesteraseinhibitorsofinterestforthetreatmentofAlzheimer"sdisease.JMedChem.2000Nov30;43(24):4657-66.PMID:11101357.

LallementG,VeyretJ,MasqueliezC,etal.Efficacyofhuperzineinpreventingsoman-inducedseizures,neuropathologicalchangesandlethality.FundamClinPharmacol.1997;11(5):387-94.PMID:9342591.

XuSS,GaoZX,WengZ,etal.Efficacyoftablethuperzine-Aonmemory,cognition,andbehaviorinAlzheimer"sdisease.ZhongguoYaoLiXueBao.1995Sep;16(5):391-5.PMID:8701750.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂