ThiscompoundisamethoxyderivativeofparentcompoundP7C3,anaminopropylcarbazolethatexhibitsantidepressantandneuroprotectiveactivities.Inanimalmodelsofchronicsocialdefeatstress,P7C3increasessurvivalofdentategyrusneurons.P7C3alsoinhibitsMPTP-inducedneuronaldeathinanimalmodelsofParkinson’sdiseaseanddelaystheonsetandpreservesmotorfunctioninanimalmodelsofamyotrophiclateralsclerosis(ALS).
| CasNo. | 1325481-43-2 |
|---|---|
| Purity | ≥98% |
| Formula | C22H20Br2N2O2 |
| FormulaWt. | 504.21 |
| Synonym | O-methoxy-P7C3,P7C3-OMe |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P0110InfoSheetPDF |
|---|
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DeJesús-CortésH,XuP,DrawbridgeJ,etal.NeuroprotectiveefficacyofaminopropylcarbazolesinamousemodelofParkinsondisease.ProcNatlAcadSciUSA.2012Oct16;109(42):17010-5.PMID:23027934.
TeslaR,WolfHP,XuP,etal.Neuroprotectiveefficacyofaminopropylcarbazolesinamousemodelofamyotrophiclateralsclerosis.ProcNatlAcadSciUSA.2012Oct16;109(42):17016-21.PMID:23027932.
