ADIpoRonisanagoNISTatadiponectinreceptorsthatincreasessecretionofAMPKandPPAR-α.AdipoRonexhibitsanti-diabeticandcardioprotectiveactivitiesandisindevelopmentasapotentialtreatmentfortype2diabetesmellitus(T2DM).Invivo,AdipoRondecreasesinsulinresistanceandglucosetolerance,amelioratesdiabetes,andincreasesLifespan.Inanimalmodelsofmyocardialischemia/reperfusion,thiscompoundimprovescardiacfunction,decreasesoxidativestress,andinhibitspost-ischemiccardiomyocyteapoptosis.
| Purity | ≥98% |
|---|---|
| Formula | C27H28N2O3・HCl・H2O |
| FormulaWt. | 483.01 |
| Solubility | HighlysolubleinDMSO.Solublein100%ethanolormethanol.Slightlysolubleinwater(1mg/ml). |
| Appearance | Whitesolid |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A1335InfoSheetPDF |
|---|
ZhangY,ZhaoJ,LiR,etal.AdipoRon,thefirstorallyactiveadiponectinreceptoractivator,attenuatespostischemicmyocardialapoptosisthroughbothAMPK-mediatedandAMPK-independentsignalings.AmJPhysiolEndocrinolMetab.2015Aug1;309(3):E275-82.PMID:26037251.
Okada-IwabuM,YamauchiT,IwabuM,etal.Asmall-moleculeAdipoRagonistfortype2diabetesandshortlifeinobesity.Nature.2013Nov28;503(7477):493-9.PMID:24172895.
