AEE-788isaninhibitorofEGFR,HER2,VEGFR2,andFLT3thatexhibitsanticancerchemotherapeuticactivity.Inanimalmodelswithependymomaxenografts,AEE-788increasessurvivalrates.Inacutemyelogenousleukemia(AML)cells,AEE-788inhibitscellproliferationandinducesapoptosis.Thiscompounddisplaysmixedresultsinaclinicalsettingduetohightoxicity.
| CasNo. | 497839-62-0 |
|---|---|
| Purity | ≥98% |
| Formula | C27H32N6 |
| FormulaWt. | 440.60 |
| IUPACName | 6-{4-[(4-Ethyl-1-piperazinyl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-1H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Synonym | AEE788,NVP-AEE788 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A1616InfoSheetPDF |
|---|
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ServideiT,MecoD,TrivieriN,etal.Effectsofepidermalgrowthfactorreceptorblockadeonependymomastemcellsinvitroandinorthotopicmousemodels.IntJCancer.2012Sep1;131(5):E791-803.PMID:22120695.
ReardonDA,ConradCA,CloughesyT,etal.PhaseIstudyofAEE788,anovelmultitargetinhibitorofErbB-andVEGF-receptor-familytyrosinekinases,inrecurrentglioblastomapatients.CancerChemotherPharmacol.2012Jun;69(6):1507-18.PMID:22392572.
BarbarrojaN,TorresLA,Rodriguez-ArizaA,etal.AEE788isavascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorwithantiproliferativeandproapoptoticeffectsinacutemyeloidleukemia.ExpHematol.2010Aug;38(8):641-52.PMID:20380868.
