1,4-DPCAisaninhibitorofprolylhydroxylasethatstABIlizesexpressionofHIF-1αandexhibitsanticancerandpro-angiogenicactivities.Inbreastcancercells,1,4-DPCAinhibitscellproliferationanddecreasesdepositionofcollagensIandIV.ThiscompoundalsolimitsgrowthofconnectivetissueonBiomaterialsandimplantedmedicaldevices.
| CasNo. | 331830-20-7 |
|---|---|
| Purity | ≥98% |
| Formula | C13H8N2O3 |
| FormulaWt. | 240.22 |
| ChemicalName | 4,4alpha-dihydro-4-oxo-1,10-phenanthroline-3-carboxylicacid |
| IUPACName | 4-Hydroxy-1,10-phenanthroline-3-carboxylicacid |
| Synonym | 1,4-Dihydrophenonthrolin-4-one-3-carboxylicacid,3-Acetyl-1H-[1,10]phenanthrolin-4-one |
| Appearance | TanPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | D6108InfoSheetPDF |
|---|
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XiongG,DengL,ZhuJ,etal.Prolyl-4-hydroxylaseαsubunit2promotesbreastcancerprogressionandmetastasisbyregulatingcollagendeposition.BMCCancer.2014Jan2;14:1.PMID:24383403.
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