Description
10-DeacetyltaxolisataxanefoundinTaxusthatexhibitsnephroprotectiveandanticanceractivities.Likeothertaxanes,thiscompoundbindstubulinandpromotesmicrotubuleassembly,preventingdepolymerization.Inanimalmodelsofpolycystickidneydisease,10-deacetyltaxolinhibitsdiseaseprogression.Thiscompoundalsoinhibitsgrowthofcervicalcarcinomacells,glioblastomacells,andneuroblastomacells.
References
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