2-Hydroxyflutamideisanon-steroidalanti-androgenthatinhibitstheandrogenreceptor.2-Hydroxyflutamideexhibitsanti-resorptiveandanticanceractivity.Inosteoblasts,2-hydroxyflutamideinhibitsproductionofIL-6andactivationofNF-κB.Inprostatecancercells,thiscompoundenhancestheefficacyofotherco-admiNISTeredchemotherapeuticssuchas5-fluorouracil.
| CasNo. | 52806-53-8 |
|---|---|
| Purity | ≥98% |
| Formula | C11H11F3N2O4 |
| FormulaWt. | 292.21 |
| ChemicalName | 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
| IUPACName | 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
| Synonym | Hydroxyniphtholide |
| MeltingPoint | 125-130°C |
| Appearance | Yellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | H9718MSDSPDF |
|---|---|
| InfoSheet | H9718InfoSheetPDF |
KawabataR,OieS,OkaT,etal.Hydroxyflutamideenhancescellularsensitivityto5-fluorouracilbysuppressingthymidylatesynthaseexpressioninbicalutamide-resistanthumanprostatecancercells.IntJOncol.2011Mar;38(3):665-76.PMID:21243325.
HofbauerLC,TenRM,KhoslaS.Theanti-androgenhydroxyflutamideandandrogensinhibitinterleukin-6productionbyanandrogen-responsivehumanosteoblasticcellline.JBoneMinerRes.1999Aug;14(8):1330-7.PMID:10457265.
FurrBJ,ValcacciaB,CurryB,etal.ICI176,334:anovelnon-steroidal,peripherallyselectiveantiandrogen.JEndocrinol.1987Jun;113(3):R7-9.PMID:3625091.
