3-Methyl adenine is an autophagy inhibitor that also inhibits DNA polymerase activity and DNA synthesis if incorporated into DNA. Additionally, 3-methyl adenine exhibits antioxidative benefit, decreasing levels of lactate dehydrogenase and ROS/RNS in hydroquinone- and rapamycin-treated cells.
| Cas No. | 5142-23-4 |
|---|---|
| Purity | ≥98% |
| Formula | C6H7N5 |
| Formula Wt. | 149.15 |
| IUPAC Name | 3-methylpurin-6-amine |
| Synonym | 3-MA, NSC 66389, NSC66389 |
| Appearance | White to off white powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | M1874 Info Sheet PDF |
|---|
Ramírez C, Pham K, Franco MF, et al. Hydroquinone induces oxidative and mitochondrial damage to human retinal Müller cells (MIO-M1). Neurotoxicology. 2013 Dec;39:102-8. PMID: 23994029.
Kumar S, Guru SK, Pathania AS, et al. Autophagy triggered by magnolol derivative negatively regulates angiogenesis. Cell Death Dis. 2013 Oct 31;4:e889. PMID: 24176847.
Johnson RE, Yu SL, Prakash S, et al. A role for yeast and human translesion synthesis DNA polymerases in promoting replication through 3-methyl adenine. Mol Cell Biol. 2007 Oct;27(20):7198-205. PMID: 17698580.
