3-MethyladenineisanautophagyinhibitorthatalsoinhibitsDNApolymeraseactivityandDNAsynthesisifincorporatedintoDNA.Additionally,3-methyladenineexhibitsantioxidativebenefit,decreasinglevelsoflactatedehydrogenaseandROS/RNSinhydroquinone-andrapamycin-treatedcells.
| CasNo. | 5142-23-4 |
|---|---|
| Purity | ≥98% |
| Formula | C6H7N5 |
| FormulaWt. | 149.15 |
| IUPACName | 3-methylpurin-6-amine |
| Synonym | 3-MA,NSC66389,NSC66389 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M1874InfoSheetPDF |
|---|
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KumarS,GuruSK,PathaniaAS,etal.Autophagytriggeredbymagnololderivativenegativelyregulatesangiogenesis.CellDeathDis.2013Oct31;4:e889.PMID:24176847.
JohnsonRE,YuSL,PrakashS,etal.AroleforyeastandhumantranslesionsynthesisDNApolymerasesinpromotingreplicationthrough3-methyladenine.MolCellBiol.2007Oct;27(20):7198-205.PMID:17698580.
