3-Phenylpropyl isothiocyanate is a synthetic isothiocyanate (ITC) that exhibits antioxidative, cytoprotective, nephroprotective, and chemopreventive activities. In vivo, this compound decreases lung tumor formation induced by benzo[a]pyrene and NNK. Additionally, this isothiocyanate increases expression and activity of heme oxygenase 1 (HO-1) and decreases renal tissue apoptosis induced by cisplatin. Like other ITCs, this compound also acts as a phase II enzyme inducer.
| Cas No. | 2627-27-2 |
|---|---|
| Purity | ≥98% |
| Formula | C10H11NS |
| Formula Wt. | 177.27 |
| Chemical Name | 3-isothiocyanatopropylbenzene |
| IUPAC Name | 3-isothiocyanatopropylbenzene |
| Synonym | Phenylpropyl isothiocyanate |
| Solubility | Soluble in DMSO. |
| Appearance | Light yellow oil |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | P2515 MSDS PDF |
|---|---|
| Info Sheet | P2515 Info Sheet PDF |
Tayem Y, Green CJ, Motterlini R, et al. Isothiocyanate-cysteine conjugates protect renal tissue against cisplatin-induced apoptosis via induction of heme oxygenase-1. Pharmacol Res. 2014 Mar;81:1-9. PMID: 24434421.
Hecht SS, Upadhyaya P, Wang M, et al. Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination. Carcinogenesis. 2002 Sep;23(9):1455-61. PMID: 12189187.
