3-Phenylpropylisothiocyanateisasyntheticisothiocyanate(ITC)thatexhibitsantioxidative,cytoprotective,nephroprotective,andchemopreventiveactivities.Invivo,thiscompounddecreaseslungtumorformationinducedbybenzo[a]pyreneandNNK.Additionally,thisisothiocyanateincreasesexpressionandactivityofhemeoxygenase1(HO-1)anddecreasesrenaltissueapoptosisinducedbycisplatin.LikeotherITCs,thiscompoundalsoactsasaphaseIIenzymeinducer.
| CasNo. | 2627-27-2 |
|---|---|
| Purity | ≥98% |
| Formula | C10H11NS |
| FormulaWt. | 177.27 |
| ChemicalName | 3-isothiocyanatopropylbenzene |
| IUPACName | 3-isothiocyanatopropylbenzene |
| Synonym | Phenylpropylisothiocyanate |
| Solubility | SolubleinDMSO. |
| Appearance | Lightyellowoil |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | P2515MSDSPDF |
|---|---|
| InfoSheet | P2515InfoSheetPDF |
TayemY,GreenCJ,MotterliniR,etal.Isothiocyanate-cysteineconjugatesprotectrenaltissueagainstcisplatin-inducedapoptosisviainductionofhemeoxygenase-1.PharmacolRes.2014Mar;81:1-9.PMID:24434421.
HechtSS,UpadhyayaP,WangM,etal.InhibitionoflungtumOrigenesisinA/JmicebyN-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteineandmyo-inositol,individuallyandincombination.Carcinogenesis.2002Sep;23(9):1455-61.PMID:12189187.
