Description
3-Tert-butyl-4-hydroxyanisole(3-BHA)isonecomponentofbutylatedhydroxyanisole(BHA).Thiscompoundiscommonlyusedasafoodadditive;itexhibitsantioxidativeandanticanceractivities.Inleukemiacells,3-BHAdecreasesthemitochondrialmembranepotential,inhibitsmitochondrialoxidativephosphorylation,inducesapoptosisandDNAdamage,andsuppressescellularproliferation.Inanimalmodels,3-BHAinducesphaseIIenzymes,increasingexpressionofquinonereductaseandglutathione-S-transferase.Somestudiessuggestthat3-BHAmayalsobemutagenic.
References
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