4-Phenylbutyl isothiocyanate (ITC) is a synthetic ITC that exhibits anticancer chemotherapeutic and chemopreventive activities. In vitro, this compound induces caspase 3-dependent apoptosis. 4-Phenylbutyl isothiocyanate inhibits the development of pancreatic dysplasia and adenocarcinoma in animal models; in other animals, it decreases the number of already formed lung tumors. Like other ITCs, this compound also acts as a phase II enzyme inducer.
| Cas No. | 61499-10-3 |
|---|---|
| Purity | ≥98% |
| Formula | C11H13NS |
| Formula Wt. | 191.31 |
| Chemical Name | 4-isothiocyanatobutylbenzene |
| IUPAC Name | 4-isothiocyanatobutylbenzene |
| Synonym | |
| Solubility | Soluble in DMSO. |
| Appearance | Colorless or slightly yellowish liquid |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | P2510 Info Sheet PDF |
|---|
Son HY, Nishikawa A, Furukawa F, et al. Modifying effects of 4-phenylbutyl isothiocyanate on N-nitrosobis(2-oxopropyl)amine-induced tumorigenesis in hamsters. Cancer Lett. 2000 Nov 28;160(2):141-7. PMID: 11053643.
Yu R, Mandlekar S, Harvey KJ, et al. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res. 1998 Feb 1;58(3):402-8. PMID: 9458080.
Guo Z, Smith TJ, Wang E, et al. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis. 1993 Jun;14(6):1167-73. PMID: 8508504.
