5-Aminosalicylicacidexhibitsanti-inflammatory,antioxidative,andanticanceractivities;itisclinicallyusedtotreatinflammatoryboweldisease(IBD),Crohn’sdisease,andcolitis,asitactsprimarilyinthecolon.Invitro,5-aminosalicylicaciddecreaseslevelsofROS,increaseslevelsofcatalaseandPPARγ,andstimulatesPTENsignaling.Incolorectalcancercells,thiscompounddecreasesproliferationbyinhibitingphospholipaseD(PLD)activityandmTORsignaling.
| CasNo. | 89-57-6 |
|---|---|
| Purity | ≥98% |
| Formula | C7H7NO3 |
| FormulaWt. | 153.14 |
| ChemicalName | 5-amino-2-hydroxybenzoicacid |
| IUPACName | 5-amino-2-hydroxybenzoicacid |
| Synonym | 5-ASA;Mesalamine;Asacol;Salofalk;5-amino-2-hydroxybenzoicacid |
| MeltingPoint | 275-280°C(dec) |
| Appearance | Awhiteoralmostwhitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | A5035MSDSPDF |
|---|---|
| InfoSheet | A5035InfoSheetPDF |
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ManagliaE,KatzmanRB,BrownJB,etal.Antioxidantpropertiesofmesalamineincolitisinhibitphosphoinositide3-kinasesignalinginProgenitorcells.InflammBowelDis.2013Sep;19(10):2051-60.PMID:23867870.
BaanB,DihalAA,HoffE,etal.5-AminosalicylicacidinhibitscellcycleprogressioninaphospholipaseDdependentmannerincolorectalcancer.Gut.2012Dec;61(12):1708-15.PMID:22187071.
