6-Mercaptopurineisathiopurineantimetabolite;itexhibitsimmunosuppressive,anti-inflammatory,andanticancerchemotherapeuticactivities.Thiscompoundisclinicallyusedtotreatinflammatoryboweldisorder(IBD),Crohn’sdisease,andleukemiasandlymphomas.Thiscompoundsuppressesmetabolismofinosinemonophosphate(IMP),inhibitingphosphoribosylpyrophosphateamidotransferase;thispreventssynthesisofpurines,DNA,andRNA.
| CasNo. | 6112-76-1 |
|---|---|
| Purity | ≥98% |
| Formula | C5H4N4S•H2O |
| FormulaWt. | 170.20 |
| ChemicalName | 1,7-Dihydro-6H-pyrine-6-thione |
| IUPACName | 3,7-dihydropurine-6-thione;hydrate |
| Synonym | Purine-6-thiol;6MP;LeukerinMercaleukin;Purinethol:6-Purinethiol |
| MeltingPoint | 313-314°C(dec.) |
| Solubility | Insolubleinwater.SolubleinMethanolandhotethanol. |
| Appearance | YellowCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M1669InfoSheetPDF |
|---|
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NielsenOH,VainerB,Rask-MadsenJ.Reviewarticle:thetreatmentofinflammatoryboweldiseasewith6-mercaptopurineorazathioprine.AlimentPharmacolTher.2001Nov;15(11):1699-708.PMID:11683683.
LennardL,WelchJC,LilleymanJS.Thiopurinedrugsinthetreatmentofchildhoodleukaemia:theinfluenceofinheritedthiopurinemethyltransferaseactivityondrugmetabolismandcytotoxicity.BrJClinPharmacol.1997Nov;44(5):455-61.PMID:9384462.
