Description
7-Triethylsilyl-baccatinIIIisasyntheticintermediateinthesynthesisoftaxol.BaccatinhastrADItionallybeenassumedtobedevoidofactivity,althoughmanystudieshaveindicatedthatbaccatinexhibitsanticancerandimmunomodulatoryactivities.Baccatindecreasesthemitochondrialmembranepotentialandinducescaspase10-dependentapoptosisinavarietyofcancercelllines,resultingininhibitionofcellproliferation.Baccatinalsoincreasestubulinassemblyandinhibitstubulindisassembly,alteringmicrotubulepolymerization.Additionally,thiscompoundincreasespresentationofantigenonMHCIandIIreceptorsondendriticcellsinvitroandinvivo.
References
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