Valnemulinhydrochlorideisapleuromutilinantibioticderivativewithanti-inflammatoryactivities.IncelllineRAW264.7,valmenulininhibitednitricoxide,prostaglandinE2,andtumornecrosisfactor-alpha.Inamousemodeloflunginjury,valnemulinwasfoundtodecreasetissueinjuryandinflammation.FurThermore,astudyonStaphylococcusaureusfoundvalnemulintogiveprolongedpostantibioticeffects.
| CasNo. | 133868-46-9 |
|---|---|
| Purity | ≥98% |
| Formula | C31H52N2O5S•HCl |
| FormulaWt. | 601.28 |
| IUPACName | (1S,2R,3S,4S,6R,7R,8R,14R)-3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.01,8]tetradec-6-yl{[2-methyl-1-(D-valylamino)-2-propanyl]sulfanyl}acetatehydrochloride(1:1) |
| Synonym | ValnemulinHCl |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | V014457InfoSheetPDF |
|---|
PoulsenSM,KarlssonM,JohanssonLB,etal.ThepleuromutilindrugstiamulinandvalnemulinbindtotheRNAatthepeptidyltransferasecentreontheribosome.MolMicrobiol,2001Sep;41(5):1091-1099.PMID:11555289.
ZhangX,LiH,XiongH,etal.Valnemulindownregulatesnitricoxide,prostaglandinE2,andcytokineproductionviainhibitionofNF-kappaBandMAPKactivity.IntImmunopharmacol.2009Jul;9(7-8):810-816.PMID:19293003.
ChenZ,ZhangX,ChuX,etal.Preventiveeffectsofvalnemulinonlipopolysaccharide-inducedacutelunginjuryinmice.Inflammation.2010Oct;33(5):306-314.PMID:20221680.
ZhaoDH,YuY,ZhouYF,etal.Postantibioticeffectandpostantibioticsub-minimuminhibitoryconcentrationeffectofvalnemulinagainstStaphylococcusaureusisolatesfromswineandchickens.LettApplMicrobiol.2014Feb;58(2):150-155.PMID:24117872.
