Description
ValproicacidactsasanantagoNISTatT-typevoltage-gatedCa2+channelsandvoltage-gatedNa+channels;italsoinhibitsGABAtransaminase,potentiatingGABAsignaling.Valproicacidisusedclinicallyasanantiepileptic/anticonvulsant,althoughitalsoexhibitsanti-inflammatory,anti-angiogenic,andanticancerchemotherapeuticactivities.Valproicacidmayalsodisplayantihypertensivebenefit.Inlungtissue,thiscompoundpreventsLPS-inducedincreasesinTNF-α,IL-1β,NF-κB,NO,andiNOS.ValproicacidisaninhibitorofclassIhistonedeacetylases(HDACs),primarilyactiveagainstHDAC1,anddownregulatesexpressionofHDAC,VEGF,VEGFR2,andFGF,inhibitingtumorgrowthandangiogenesisinanimalmodels.
References
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