LKT/缬沙坦/V0146/5克-免疫在线蚂蚁淘旗下平台

商品详细LKT/缬沙坦/V0146/5克

LKT/缬沙坦/V0146/5克

商品编号： V0146-5g

品牌： lktlabs

市场价： ¥1660.00

美元价： 996.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDV0146

CasNo.137862-53-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

ValsartanisanangiotensinII(ATII)type1receptor(AT1)inhibitorthatisclinicallyusedtolowerbloodpressureandcoronaryresistance,andtodecreasecardiachypertrophy.Valsartanexhibitsantihypertensive,cardioprotective,neuroprotective,anti-angiogenic,andanti-inflammatoryactivities.InhibitionoftheATIItype1receptorresultsininhibitionofNF-κBandAP-1activation.ValsartaninducesautophagythroughalterationofAkt/mTORsignalingintheratheart,decreasinginfarctsizeinanischemia-reperfusionmodel.Inneurons,valsartanpromotesspinogenesis,increasingthenumberofAMPAreceptorsonthecellsurfaceandalteringlevelsofCaMKIIαandphospho-CDK5.Invivo,valsartanpreventsinductionofcardiotrophin-1,inhibitingincreasesincreatinekinase,atrialnatriureticpeptide,andtheheartweight/bodyweightratioduringheartfailure.Additionally,inhibitionoftheangiotensinIItype1(AT1)receptorpreventsphosphorylationofAktanddecreasesexpressionofVEGFinbonemarrowstromalcells.Valsartanalsoinhibitsreleaseofpro-inflammatorycytokinessuchasIL-6,TNF-α,andIL-1βindependentofitsactivityonATIItype1receptors.

ProductInfo

CasNo.	137862-53-4
Purity	≥98%
Formula	C₂₄H₂₉N₅O₃
FormulaWt.	435.52
ChemicalName	N-(1-Oxopentyl)-N-[[2’-1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-L-valine
IUPACName	(2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoicacid
MeltingPoint	116-117°C
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	V0146InfoSheetPDF

References

WuX,HeL,CaiY,etal.Inductionofautophagycontributestothemyocardialprotectionofvalsartanagainstischemiareperfusioninjury.MolMedRep.2013Dec;8(6):1824-30.PMID:24084854.

SohnYI,LeeNJ,ChungA,etal.AntihypertensivedrugValsartanpromotesdendriticspinedensitybyalteringAMPAreceptortrafficking.BiochemBiophysResCommun.2013Oct4;439(4):464-70.PMID:24012668.

ChengCI,HsiaoCC,WuSC,etal.ValsartanimpairsangiogenesisofmesenchymalstemcellsthroughAktpathway.IntJCardiol.2013Sep10;167(6):2765-74.PMID:22805546.

Al-MazrouaHA,Al-RasheedNM,KorashyHM.Downregulationofthecardiotrophin-1geneexpressionbyvalsartanandspironolactoneinhypertrophiedheartratsinvivoandratcardiomyocyteH9c2celllineinvitro:anovelmechanismofcardioprotection.JCardiovascPharmacol.2013Apr;61(4):337-44.PMID:23288202.

IwashitaM,SakodaH,KushiyamaA,etal.Valsartan,independentlyofAT1receptororPPARγ,suppressesLPS-inducedmacrophageactivationandimprovesinsulinresistanceincoculturedADIpocytes.AmJPhysiolEndocrinolMetab.2012Feb1;302(3):E286-96.PMID:22045314.

MüllerDN,MervaalaEM,DechendR,etal.AngiotensinII(AT(1))receptorblockadereducesvasculartissuefactorinangiotensinII-inducedcardiacvasculopathy.AmJPathol.2000Jul;157(1):111-22.PMID:10880382.

IzumiS,NozakiY,MaedaK,etal.Investigationoftheimpactofsubstrateselectiononinvitroorganicaniontransportingpolypeptide1B1inhibitionprofilesforthepredictionofdrug-druginteractions.DrugMetabDispos.2015Feb;43(2):235-247.PMID:25414411.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂