Description
Vandetanibisananticancerchemotherapeuticandanti-angiogeniccompoundthatactsasanATP-competitiveinhibitorofRET,EGFR,andVEGFR2.Inacellularmodelofmedullarythyroidcarcinoma,vandetanibinhibitsphosphorylationofRET,Shc,andMAPKs,inhibitingcellproliferation.Inglioblastomacells,vandetanibinducesautophagyandapoptosis,andinasimilarinvivomodel,preventstumorgrowth.Inseparateanimalmodels,vandetanib’sinhibitionofVEGFR2decreasestumormicrovesseldensityandtumorcellproliferation.VandetanibalsoinduceshypertensionandprolongsthecardiacQTintervalinclinicalsettings.
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