Veliparibisanoralpoly(ADP-ribose)polymerase(PARP)inhibitorthatshowsanticancerchemotherapeuticandanti-inflammatoryactivities.Veliparibcrossestheblood-brainbarrierwitha3:1plasma:braindrugratio.InhibitionofPARPbyveliparibpreventsexcessiveinflammationinanimalmodelsofcysticfibrosisandinhibitsrepairofDNAdamagecausedbychemotherapyorrADIationinavarietyofcancermodels.
| CasNo. | 912444-00-9 |
|---|---|
| Purity | ≥99% |
| Formula | C13H16N4O |
| FormulaWt. | 244.29 |
| IUPACName | 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide |
| Synonym | ABT-888 |
| Solubility | DMSO(>15mg/mL,or>50mM). |
| Appearance | off-whitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | V1745MSDSPDF |
|---|---|
| InfoSheet | V1745InfoSheetPDF |
| Brochures | PARPInhibitorsFlyer |
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BarazzuolL,JenaR,BurnetNG,etal.Evaluationofpoly(ADP-ribose)polymeraseinhibitorABT-888combinedwithradiotherapyandtemozolomideinglioblastoma.RadiatOncol.2013Mar19;8:65.PMID:23510353.
TaLE,SchmelzerJD,BieberAJ,etal.Anovelandselectivepoly(ADP-ribose)polymeraseinhibitorameliorateschemotherapy-inducedpainfulneuropathy.PLoSOne.2013;8(1):e54161.PMID:23326593.
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