Vinblastine is a vinca alkaloid found in Catharanthus that exhibits immunosuppressive and anticancer chemotherapeutic activities. Vinblastine is an anti-mitotic that binds tubulin and inhibits proper microtubule polymerization, instead causing formation of curved or misshapen microtubules; it is clinically used to treat lymphomas, leukemias, breast cancer, and non-small cell lung cancer (NSCLC).
| Cas No. | 143-67-9 |
|---|---|
| Purity | ≥96% |
| Formula | C46H58N4O9S • H2SO4 |
| Formula Wt. | 909.07 |
| Chemical Name | Vincaleukblastine sulfate |
| Synonym | Exal; Velban; Velbe |
| Melting Point | 267°C |
| Solubility | Slightly soluble in ethanol or water (10 parts). Practically insoluble in ether. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | V3253 Info Sheet PDF |
|---|
Pliarchopoulou K, Laschos K, Pectasides D. Current chemotherapeutic options for the treatment of advanced bladder cancer: a review. Urol Oncol. 2013 Apr;31(3):294-302. PMID: 20843708.
Rendine S, Pieraccini S, Sironi M. Vinblastine perturbation of tubulin protofilament structure: a computational insight. Phys Chem Chem Phys. 2010 Dec 21;12(47):15530-6. PMID: 20978652.
Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004 Apr;4(4):253-65. PMID: 15057285.
