Vincristine is a vinca alkaloid found in Catharanthus that exhibits immunosuppressive and anticancer chemotherapeutic activities. Vincristine is an anti-mitotic that binds tubulin and inhibits microtubule polymerization; it is clinically used to treat lymphomas and leukemias and is one component of the CHOP chemotherapy cocktail. In melanoma cells, vincristine increases activation of AMPK and inhibition of mTORC1 signaling.
| Cas No. | 2068-78-2 |
|---|---|
| Purity | ≥98% |
| Formula | C46H56N4O10S • H2SO4 |
| Formula Wt. | 923.05 |
| Chemical Name | 22-Oxovincaleukoblastine sulfate |
| Synonym | Kyocristine; Oncovin; Vincrex |
| Melting Point | 273-281°C |
| Solubility | Soluble in water. Slightly soluble in ethanol or chloroform. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | V5254 Info Sheet PDF |
|---|
Wang L, Xia ZJ, Huang HQ, et al. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type: 13-year follow-up in 135 patients. Int J Hematol. 2012 Nov;96(5):617-23. PMID: 22983648.
Chen MB, Shen WX, Yang Y, et al. Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell. J Cell Physiol. 2011 Jul;226(7):1915-25. PMID: 21506122.
Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004 Apr;4(4):253-65. PMID: 15057285.
