VincristineisavincaalkaloidfoundinCatharanthusthatexhibitsimmunosuppressiveandanticancerchemotherapeuticactivities.Vincristineisananti-mitoticthatbindstubulinandinhibitsmicrotubulepolymerization;itisclinicallyusedtotreatlymphomasandleukemiasandisonecomponentoftheCHOPchemotherapycocktail.Inmelanomacells,vincristineincreasesactivationofAMPKandinhibitionofmTORC1signaling.
| CasNo. | 2068-78-2 |
|---|---|
| Purity | ≥98% |
| Formula | C46H56N4O10S•H2SO4 |
| FormulaWt. | 923.05 |
| ChemicalName | 22-Oxovincaleukoblastinesulfate |
| Synonym | Kyocristine;Oncovin;Vincrex |
| MeltingPoint | 273-281°C |
| Solubility | Solubleinwater.Slightlysolubleinethanolorchloroform. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | V5254InfoSheetPDF |
|---|
WangL,XiaZJ,HuangHQ,etal.Cyclophosphamide,doxorubicin,vincristine,andprednisone(CHOP)inthetreatmentofstageIE/IIEextranodalnaturalkiller/Tcelllymphoma,nasaltype:13-yearfollow-upin135patients.IntJHematol.2012Nov;96(5):617-23.PMID:22983648.
ChenMB,ShenWX,YangY,etal.ActivationofAMP-activatedproteinkinaseisinvolvedinvincristine-inducedcellapoptosisinB16melanomacell.JCellPhysiol.2011Jul;226(7):1915-25.PMID:21506122.
JordanMA,WilsonL.Microtubulesasatargetforanticancerdrugs.NatRevCancer.2004Apr;4(4):253-65.PMID:15057285.
