Vinorelbineisasemi-syntheticvincaalkaloidoriginallyfoundinCatharanthusthatexhibitsanticancerchemotherapeuticactivity.Vinorelbinebindsβ-tubulinandstimulatesmicrotubuledepolymerization,actingasananti-mitotic.Vinorelbineisclinicallyusedtotreatbreastcancerandnon-smallcelllungcancer(NSCLC).Inosteosarcomacells,vinorelbinedownregulatesexpressionofcyclinD1andupregulatesexpressionofp53,inhibitingcellgrowth.
| CasNo. | 125317-39-7 |
|---|---|
| Purity | ≥98% |
| Formula | C45H54N4O8•2C4H6O6 |
| FormulaWt. | 1079.10 |
| ChemicalName | 3",4"-Didehydro-4"-deoxy-C"-norvincaleukoblastineditartrate |
| Synonym | Eunades;Navelbine |
| MeltingPoint | 219°C |
| Solubility | Solubleinwaterandethanol. |
| Appearance | Off-whiteorlightbrownpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | V3252MSDSPDF |
|---|---|
| InfoSheet | V3252InfoSheetPDF |
CapassoA.Vinorelbineincancertherapy.CurrDrugTargets.2012Jul;13(8):1065-71.PMID:22594474.
RoncuzziL,MartiG,BaiocchiD,etal.EffectofVinorelbineoncellgrowthandapoptosisinductioninhumanosteosarcomainvitro.OncolRep.2006Jan;15(1):73-7.PMID:16328036.
